I love following certain gaming channels for about one or two of their usual ongoing Let's Plays but they frequently "spam" my subscription page with 80% of their content that I just don't care for. This makes it much harder to see content from other creators sometimes. So I set those specific titles, usually X Plays Y, as blocked. Now all I get is what I subscribed for. This should be a feature Youtube offers by default but don't.

It's easy to set up, easy to block stuff with, and you see the results instantly without refreshing so you can immediately rectify any mistakes you may have made. I cannot recommend this enough and will donate once I'm able to.